Open AccessA proteomic approach to obesity and type 2 diabetes
Author(s) -
LópezVillar Elena,
MartosMoreno Gabriel Á.,
Chowen Julie A.,
Okada Shigeru,
Kopchick John J.,
Argente Jesús
Publication year - 2015
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12600
Subject(s) - type 2 diabetes , proteomics , identification (biology) , obesity , bioinformatics , omics , proteome , diabetes mellitus , medicine , human proteome project , relevance (law) , computational biology , data science , biology , computer science , pathology , endocrinology , political science , biochemistry , botany , gene , law
The incidence of obesity and type diabetes 2 has increased dramatically resulting in an increased interest in its biomedical relevance. However, the mechanisms that trigger the development of diabetes type 2 in obese patients remain largely unknown. Scientific, clinical and pharmaceutical communities are dedicating vast resources to unravel this issue by applying different omics tools. During the last decade, the advances in proteomic approaches and the Human Proteome Organization have opened and are opening a new door that may be helpful in the identification of patients at risk and to improve current therapies. Here, we briefly review some of the advances in our understanding of type 2 diabetes that have occurred through the application of proteomics. We also review, in detail, the current improvements in proteomic methodologies and new strategies that could be employed to further advance our understanding of this pathology. By applying these new proteomic advances, novel therapeutic and/or diagnostic protein targets will be discovered in the obesity/Type 2 diabetes area.