Cardiac regenerative potential of cardiosphere‐derived cells from adult dog hearts | Zendy

Hensley Michael Taylor | Zendy; Andrade James | Zendy; Keene Bruce | Zendy; Meurs Kathryn | Zendy; Tang Junnan | Zendy; Wang Zegen | Zendy; Caranasos Thomas G. | Zendy; Piedrahita Jorge | Zendy; Li TaoSheng | Zendy; Cheng Ke | Zendy

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Cardiac regenerative potential of cardiosphere‐derived cells from adult dog hearts

Author(s) -

Hensley Michael Taylor,

Andrade James,

Keene Bruce,

Meurs Kathryn,

Tang Junnan,

Wang Zegen,

Caranasos Thomas G.,

Piedrahita Jorge,

Li TaoSheng,

Cheng Ke

Publication year - 2015

Publication title -

journal of cellular and molecular medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.44

H-Index - 130

eISSN - 1582-4934

pISSN - 1582-1838

DOI - 10.1111/jcmm.12585

Subject(s) - myocyte , cardiac function curve , angiogenesis , dilated cardiomyopathy , stem cell , cardiomyopathy , regenerative medicine , biology , pathology , medicine , microbiology and biotechnology , heart failure

The regenerative potential of cardiosphere‐derived cells ( CDC s) for ischaemic heart disease has been demonstrated in mice, rats, pigs and a recently completed clinical trial. The regenerative potential of CDC s from dog hearts has yet to be tested. Here, we show that canine CDC s can be produced from adult dog hearts. These cells display similar phenotypes in comparison to previously studied CDC s derived from rodents and human beings. Canine CDC s can differentiate into cardiomyocytes, smooth muscle cells and endothelial cells in vitro . In addition, conditioned media from canine CDC s promote angiogenesis but inhibit cardiomyocyte death. In a doxorubicin‐induced mouse model of dilated cardiomyopathy ( DCM ), intravenous infusion of canine CDC s improves cardiac function and decreases cardiac fibrosis. Histology revealed that injected canine CDC s engraft in the mouse heart and increase capillary density. Out study demonstrates the regenerative potential of canine CDC s in a mouse model of DCM .

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