Open AccessAntibacterial, antifungal and in vitro antileukaemia activity of metal complexes with thiosemicarbazones
Author(s) -
Pahontu Elena,
Julea Felicia,
Rosu Tudor,
Purcarea Victor,
Chumakov Yurie,
Petrenco Petru,
Gulea Aurelian
Publication year - 2015
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12508
Subject(s) - molar conductivity , chemistry , ligand (biochemistry) , vanadium , crystallography , square pyramidal molecular geometry , semicarbazone , magnetic susceptibility , copper , electron paramagnetic resonance , metal , stereochemistry , crystal structure , inorganic chemistry , nuclear magnetic resonance , organic chemistry , biochemistry , receptor , physics
1‐phenyl‐3‐methyl‐4‐benzoyl‐5‐pyrazolone 4‐ethyl‐thiosemicarbazone ( HL ) and its copper(II), vanadium(V) and nickel(II) complexes: [ Cu ( L )( Cl )]·C 2 H 5 OH·( 1 ), [ Cu (L) 2 ]· H 2 O ( 2 ), [ Cu ( L )( Br )]· H 2 O ·CH 3 OH ( 3 ), [ Cu ( L )( NO 3 )]·2C 2 H 5 OH ( 4 ), [VO 2 (L)]·2 H 2 O ( 5 ), [ Ni ( L ) 2 ]· H 2 O ( 6 ), were synthesized and characterized. The ligand has been characterized by elemental analyses, IR , 1 H NMR and 13 C NMR spectroscopy. The tridentate nature of the ligand is evident from the IR spectra. The copper(II), vanadium(V) and nickel(II) complexes have been characterized by different physico‐chemical techniques such as molar conductivity, magnetic susceptibility measurements and electronic, infrared and electron paramagnetic resonance spectral studies. The structures of the ligand and its copper(II) ( 2 , 4 ), and vanadium(V) ( 5 ) complexes have been determined by single‐crystal X‐ray diffraction. The composition of the coordination polyhedron of the central atom in 2 , 4 and 5 is different. The tetrahedral coordination geometry of Cu was found in complex 2 while in complex 4 , it is square planar, in complex 5 the coordination polyhedron of the central ion is distorted square pyramid. The in vitro antibacterial activity of the complexes against E scherichia coli , S almonella abony , S taphylococcus aureus , B acillus cereus and the antifungal activity against C andida albicans strains was higher for the metal complexes than for free ligand. The effect of the free ligand and its metal complexes on the proliferation of HL ‐60 cells was tested.