Open AccessDehydrozingerone exerts beneficial metabolic effects in high‐fat diet‐induced obese mice via AMPK activation in skeletal muscle
Author(s) -
Kim Su Jin,
Kim Hong Min,
Lee Eun Soo,
Kim Nami,
Lee Jung Ok,
Lee Hye Jeong,
Park Na Yeon,
Jo Joo Yeon,
Ham Bo Young,
Han Si Hyun,
Park Sun Hwa,
Chung Choon Hee,
Kim Hyeon Soo
Publication year - 2015
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12455
Subject(s) - ampk , skeletal muscle , endocrinology , chemistry , medicine , amp activated protein kinase , microbiology and biotechnology , biology , protein kinase a , biochemistry , phosphorylation
Dehydrozingerone ( DHZ ) exerts beneficial effects on human health; however, its mechanism of action remains unclear. Here, we found that DHZ suppressed high‐fat diet‐induced weight gain, lipid accumulation and hyperglycaemia in C57 BL /6 mice and increased AMP ‐activated protein kinase ( AMPK ) phosphorylation and stimulated glucose uptake in C2C12 skeletal muscle cells. DHZ activated p38 mitogen‐activated protein kinase ( MAPK ) signalling in an AMPK ‐dependent manner. Inhibiting AMPK or p38 MAPK blocked DHZ ‐induced glucose uptake. DHZ increased GLUT 4 (major transporter for glucose uptake) expression in skeletal muscle. Glucose clearance and insulin‐induced glucose uptake increased in DHZ ‐fed animals, suggesting that DHZ increases systemic insulin sensitivity in vivo . Thus, the beneficial health effects of DHZ could possibly be explained by its ability to activate the AMPK pathway in skeletal muscle.