Open AccessAntibody‐ and aptamer‐strategies for Gv HD prevention
Author(s) -
Oelkrug Christopher,
Sack Ulrich,
Boldt Andreas,
Nascimento Isis C.,
Ulrich Henning,
Fricke Stephan
Publication year - 2015
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12416
Subject(s) - aptamer , immunology , antibody , graft versus host disease , immune system , antigen , hematopoietic stem cell transplantation , medicine , transplantation , haematopoiesis , stem cell , disease , biology , microbiology and biotechnology , genetics
Abstract Prevention of Graft‐ versus ‐Host‐Disease (Gv HD ) by preserved Graft‐ versus ‐Leukaemia (GvL) effect is one of the major obstacles following allogeneic haematopoietic stem cell transplantation. Currently used drugs are associated with side effects and were not able to separate Gv HD from the GvL‐effect because of general T‐cell suppression. This review focuses on murine models for Gv HD and currently available treatment options involving antibodies and applications for the therapeutic use of aptamers as well as strategies for targeting immune responses by allogenic antigens.