Open AccessThe role of the cell–cell interactions in cancer progression
Author(s) -
Kamińska Katarzyna,
Szczylik Cezary,
Bielecka Zofia F.,
Bartnik Ewa,
Porta Camillo,
Lian Fei,
Czarnecka Anna M.
Publication year - 2015
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12408
Subject(s) - stromal cell , biology , carcinogenesis , cancer cell , transcriptome , proteome , cell , microbiology and biotechnology , signal transduction , tumor microenvironment , cancer research , cancer , cell signaling , gene , gene expression , bioinformatics , genetics
In the field of cancer research, scientific investigations are based on analysing differences in the secretome, the proteome, the transcriptome, the expression of cell surface molecules, and the deregulation of signal transduction pathways between neoplastic and normal cells. Accumulating evidence indicates a crucial role in carcinogenesis concerning not only stromal cells but also normal cells from target organs and tissue where tumours emerge. The tumour microenvironment ( TME ) definitively plays an important role in regulating neighbouring cell behaviour. To date, limited attention has been focused upon interactions between cancer cells and normal cells. This review concentrates on the interactions between stromal and healthy cells from the TME in cancer development. In the article, the authors also describe mutations, genes and proteins expression pattern that are involved in tumour development in target organ.