Open AccessAnchored protein kinase A signalling in cardiac cellular electrophysiology
Author(s) -
Soni Siddarth,
Scholten Arjen,
Vos Marc A.,
Veen Toon A.B.
Publication year - 2014
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12365
Subject(s) - protein kinase a , microbiology and biotechnology , cyclic adenosine monophosphate , adenosine , signal transduction , kinase , electrophysiology , second messenger system , signalling , cardiac electrophysiology , protein subunit , ion channel , chemistry , biology , neuroscience , biochemistry , receptor , gene
The cyclic adenosine monophosphate (c AMP )‐dependent protein kinase ( PKA ) is an elementary molecule involved in both acute and chronic modulation of cardiac function. Substantial research in recent years has highlighted the importance of A‐kinase anchoring proteins ( AKAP ) therein as they act as the backbones of major macromolecular signalling complexes of the β‐adrenergic/c AMP / PKA pathway. This review discusses the role of AKAP ‐associated protein complexes in acute and chronic cardiac modulation by dissecting their role in altering the activity of different ion channels, which underlie cardiac action potential ( AP ) generation. In addition, we review the involvement of different AKAP complexes in mechanisms of cardiac remodelling and arrhythmias.