Open AccessMicro RNA ‐145: a potent tumour suppressor that regulates multiple cellular pathways
Author(s) -
Cui ShiYun,
Wang Rui,
Chen LongBang
Publication year - 2014
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12358
Subject(s) - rna , biology , messenger rna , untranslated region , microrna , suppressor , competing endogenous rna , long non coding rna , non coding rna , gene expression , microbiology and biotechnology , gene , rna binding protein , cancer research , genetics
Micro RNA s are endogenous, small (18–25 nucleotides) non‐coding RNA s, which regulate genes expression by directly binding to the 3′‐untranslated regions of the target messenger RNA s. Emerging evidence shows that alteration of micro RNA s is involved in cancer development. Micro RNA ‐145 is commonly down‐regulated in many types of cancer, regulating various cellular processes, such as the cell cycle, proliferation, apoptosis and invasion, by targeting multiple oncogenes. This review aims to summarize the recent published literature on the role of micro RNA ‐145 in regulating tumourigenesis and progression, and explore its potential for cancer diagnosis, prognosis and treatment.