Open AccessProteomics‐based discovery of biomarkers for paediatric acute lymphoblastic leukaemia: challenges and opportunities
Author(s) -
López Villar Elena,
Wu Duojiao,
Cho William C.,
Madero Luis,
Wang Xiangdong
Publication year - 2014
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12319
Subject(s) - proteomics , medicine , disease , biomarker , bioinformatics , biomarker discovery , bone marrow , omics , blood cancer , intensive care medicine , cancer , immunology , pathology , biology , biochemistry , gene
Abstract There are important breakthroughs in the treatment of paediatric acute lymphoblastic leukaemia ( ALL ) since 1950, by which the prognosis of the child majority suffered from ALL has been improved. However, there are urgent needs to have disease‐specific biomarkers to monitor the therapeutic efficacy and predict the patient prognosis. The present study overviewed proteomics‐based research on paediatric ALL to discuss important advances to combat cancer cells and search novel and real protein biomarkers of resistance or sensitivity to drugs which target the signalling networks. We highlighted the importance and significance of a proper phospho‐quantitative design and strategy for paediatric ALL between relapse and remission, when human body fluids from cerebrospinal, peripheral blood, or bone‐marrow were applied. The present article also assessed the schedule for the analysis of body fluids from patients at different states, importance of proteomics‐based tools to discover ALL ‐specific and sensitive biomarkers, to stimulate paediatric ALL research via proteomics to ‘build’ the reference map of the signalling networks from leukemic cells at relapse, and to monitor significant clinical therapies for ALL ‐relapse.