Open AccessAssociation of the variants in the BUD 13‐ ZNF 259 genes and the risk of hyperlipidaemia
Author(s) -
Aung Lynn Htet Htet,
Yin RuiXing,
Wu DongFeng,
Wang Wei,
Liu ChengWu,
Pan ShangLing
Publication year - 2014
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12291
Subject(s) - single nucleotide polymorphism , haplotype , allele , locus (genetics) , genotyping , biology , genotype , genetics , snp , multifactor dimensionality reduction , gene , medicine
The single nucleotide polymorphisms ( SNP s) in the BUD 13 homolog ( BUD 13) and zinc finger protein 259 ( ZNF 259) genes have been associated with one or more serum lipid traits in the E uropean populations. However, little is known about such association in the C hinese populations. Our objectives were to determine the association of the BUD 13 / ZNF 259 SNP s and their haplotypes with hypercholesterolaemia ( HCH )/hypertriglyceridaemia ( HTG ) and to identify the possible gene–gene interactions among these SNP s. Genotyping of 6 SNP s was performed in 634 hyperlipidaemic and 547 normolipidaemic participants. The ZNF 259 rs2075290, ZNF 259 rs964184 and BUD 13 rs10790162 SNP s were significantly associated with serum lipid levels in both HCH and non‐ HCH populations ( P < 0.008–0.001). On single locus analysis, only BUD 13 rs10790162 was associated with HCH ( OR : 2.23, 95% CI : 1.05, 4.75, P = 0.015). The G‐G‐A‐A‐C‐C haplotype, carrying rs964184‐G‐allele, was associated with increased risk of HCH ( OR : 1.35, 95% CI : 1.10, 1.66, P = 0.005) and HTG ( OR : 1.75, 95% CI : 1.39, 2.21, P = 0.000). The A‐C‐G‐G‐C‐C and A‐C‐A‐G‐T‐C haplotypes, carrying rs964184‐C‐allele, were associated with reduced risk of HCH ( OR : 0.77, 95% CI : 0.61, 0.99, P = 0.039 and OR : 0.66, 95% CI : 0.47, 0.94, P = 0.021 respectively). On multifactor dimensionality reduction analyses, the two‐ to three‐locus models showed a significant association with HCH and HTG ( P < 0.01–0.001). The BUD 13/ ZNF 259 SNP s, which were significant in the E uropean populations, are also replicable in the S outhern C hinese population. Moreover, inter‐locus interactions may exist among these SNP s. However, further functional studies are required to clarify how these SNP s and genes actually affect the serum lipid levels.