Open AccessIntramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post‐infarcted cardiac function in rats
Author(s) -
Zhao Baoyin,
Liao Zhaofu,
Chen Shang,
Yuan Ziqiang,
Yilin Chen,
Lee Kenneth K.H.,
Qi Xufeng,
Shen Xiaotao,
Zheng Xin,
Quinn Thomas,
Cai Dongqing
Publication year - 2014
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12259
Subject(s) - cardiology , myocardial infarction , medicine , cardiac function curve , transplantation , heart transplantation , heart failure
The midterm effects of cardiac telocytes ( CT s) transplantation on myocardial infarction ( MI ) and the cellular mechanisms involved in the beneficial effects of CT s transplantation are not understood. In the present study, we have revealed that transplantation of CT s was able to significantly decrease the infarct size and improved cardiac function 14 weeks after MI . It has established that CT transplantation exerted a protective effect on the myocardium and this was maintained for at least 14 weeks. The cellular mechanism behind this beneficial effect on MI was partially attributed to increased cardiac angiogenesis, improved reconstruction of the CT network and decreased myocardial fibrosis. These combined effects decreased the infarct size, improved the reconstruction of the LV and enhanced myocardial function in MI . Our findings suggest that CT s could be considered as a potential cell source for therapeutic use to improve cardiac repair and function following MI , used either alone or in tandem with stem cells.