Open AccessAmniotic mesenchymal stem cells display neurovascular tropism and aid in the recovery of injured peripheral nerves
Author(s) -
Li YongNan,
Guo Longzhe,
Ahn Hyun Sook,
Kim Moo Hyun,
Kim SungWhan
Publication year - 2014
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12249
Subject(s) - mesenchymal stem cell , vascularity , medicine , transplantation , pathology , stem cell , sciatic nerve , tropism , neurovascular bundle , anatomy , microbiology and biotechnology , immunology , biology , surgery , virus
Recently, we reported that human amniotic membrane‐derived mesenchymal stem cells ( AMM s) possess great angiogenic potential. In this study, we determined whether local injection of AMM s ameliorates peripheral neuropathy. AMM s were transplanted into injured sciatic nerves. AMM injection promoted significant recovery of motor nerve conduction velocity and voltage amplitude compared to human adipose‐derived mesenchymal stem cells. AMM implantation also augmented blood perfusion and increased intraneural vascularity. Whole‐mount fluorescent imaging analysis demonstrated that AMM s exhibited higher engraftment and endothelial incorporation abilities in the sciatic nerve. In addition, the higher expression of pro‐angiogenic factors was detected in AMM s injected into the peripheral nerve. Therefore, these data provide novel therapeutic and mechanistic insights into stem cell biology, and AMM transplantation may represent an alternative therapeutic option for treating peripheral neuropathy.