Open AccessTAP1 I333V gene polymorphism and type 1 diabetes mellitus: a meta‐analysis of 2248 cases
Author(s) -
Li YanYan,
Gao Wei,
Pang SiSi,
Min XiaoYan,
Yang ZhiJian,
Wang Hui,
Lu XinZheng,
Wang LianSheng,
Wang XiangMing,
Qian Yun,
Zhou ChuanWei,
Wu Jun,
Chen AiLing
Publication year - 2014
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12244
Subject(s) - allele , genetic model , polymorphism (computer science) , meta analysis , type 1 diabetes , confidence interval , genetics , gene polymorphism , medicine , biology , gene , diabetes mellitus , gastroenterology , endocrinology
Transporter associated with antigen processing 1 ( TAP 1 ) I333V gene polymorphism has been suggested to be associated with type 1 diabetes mellitus (T1 DM ) susceptibility. However, the results from individual studies are inconsistent. To explore the association of TAP 1 I333V gene polymorphisms with T1 DM , a meta‐analysis involving 2246 cases from 13 individual studies was conducted. The pooled odd ratios ( OR s) and their corresponding 95% confidence intervals (95% CI s) were evaluated by a fixed‐effect model. A significant relationship was observed between TAP 1 I333V gene polymorphism and T1 DM in allelic ( OR : 1.35, 95% CI : 1.08–1.68, P = 0.007), dominant ( OR : 1.462, 95% CI : 1.094–1.955, P = 0.010), homozygous ( OR : 1.725, 95% CI : 1.082–2.752, P = 0.022), heterozygous ( OR : 1.430, 95% CI : 1.048–1.951, P = 0.024) and additive ( OR : 1.348, 95% CI : 1.084–1.676, P = 0.007) genetic models. No significant association between TAP 1 I333V gene polymorphism and T1 DM was detected in a recessive genetic model ( OR : 1.384, 95% CI : 0.743–2.579, P = 0.306) in the entire population, especially among Caucasians. No significant association between them was found in an Asian or African population. TAP 1 I333V gene polymorphism was significantly associated with increased T1 DM risk. V allele carriers might be predisposed to T1 DM susceptibility.