Open AccessKCNQ 1 rs2237892 C→T gene polymorphism and type 2 diabetes mellitus in the Asian population: a meta‐analysis of 15,736 patients
Author(s) -
Li Yanyan,
Wang Xiangming,
Lu Xinzheng
Publication year - 2014
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12185
Subject(s) - odds ratio , meta analysis , allele , genetics , polymorphism (computer science) , population , confidence interval , subgroup analysis , biology , genetic model , gene polymorphism , medicine , gene , environmental health
The KCNQ 1 rs2237892 C→T gene polymorphism is reportedly associated with T2 DM susceptibility, but various studies show conflicting results. To explore this association in the Asian population, a meta‐analysis of 15,736 patients from 10 individual studies was performed. The pooled odds ratios ( OR s) and their 95% confidence intervals ( CI s) were evaluated using random‐effect or fixed‐effect models. A significant relationship between the KCNQ 1 rs2237892 C→T gene polymorphism and T2 DM was observed in the Asian population under the allelic ( OR , 1.350; 95% CI , 1.240–1.480; P < 0.00001), recessive ( OR : 0.650; 95% CI : 0.570–0.730; P < 0.00001), dominant ( OR : 1.450; 95% CI : 1.286–1.634; P < 0.00001), and additive ( OR : 1.346; 95% CI : 1.275–1.422; P < 0.00001) genetic models. In the subgroup analysis by race, a significant association was found in C hinese, K orean and M alaysia population, but not in Indian population. KCNQ 1 rs2237892 C→T gene polymorphism was found to be significantly associated with increased T2 DM risk in the A sian population, except Indian population. The C allele of the KCNQ 1 rs2237892 C→T gene polymorphism may confer susceptibility to T2 DM .