KCNQ 1 rs2237892 C→T gene polymorphism and type 2 diabetes mellitus in the Asian population: a meta‐analysis of 15,736 patients

The KCNQ 1 rs2237892 C→T gene polymorphism is reportedly associated with T2 DM susceptibility, but various studies show conflicting results. To explore this association in the Asian population, a meta‐analysis of 15,736 patients from 10 individual studies was performed. The pooled odds ratios ( OR s) and their 95% confidence intervals ( CI s) were evaluated using random‐effect or fixed‐effect models. A significant relationship between the KCNQ 1 rs2237892 C→T gene polymorphism and T2 DM was observed in the Asian population under the allelic ( OR , 1.350; 95% CI , 1.240–1.480; P  < 0.00001), recessive ( OR : 0.650; 95% CI : 0.570–0.730; P  < 0.00001), dominant ( OR : 1.450; 95% CI : 1.286–1.634; P  < 0.00001), and additive ( OR : 1.346; 95% CI : 1.275–1.422; P  < 0.00001) genetic models. In the subgroup analysis by race, a significant association was found in C hinese, K orean and M alaysia population, but not in Indian population. KCNQ 1 rs2237892 C→T gene polymorphism was found to be significantly associated with increased T2 DM risk in the A sian population, except Indian population. The C allele of the KCNQ 1 rs2237892 C→T gene polymorphism may confer susceptibility to T2 DM .