Open AccessCancer‐related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes
Author(s) -
Dmitriev Petr,
Kairov Ulykbek,
Robert Thomas,
Barat Ana,
Lazar Vladimir,
Carnac Gilles,
LaoudjChenivesse Dalila,
Vassetzky Yegor S.
Publication year - 2014
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12182
Subject(s) - myogenesis , myotonic dystrophy , facioscapulohumeral muscular dystrophy , transcriptome , cancer , gene , biology , cancer research , genetics , muscular dystrophy , gene expression
Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral dystrophy ( FSHD ) and cancer by comparing published transcriptome signatures of FSHD and various malignant tumours and have found a significant enrichment of cancer‐related genes among the genes differentially expressed in FSHD . The analysis has shown that gene expression profiles of FSHD myoblasts and myotubes resemble that of Ewing's sarcoma more than that of other cancer types tested. This is the first study demonstrating a similarity between FSHD and cancer cell expression profiles, a finding that might indicate the existence of a common step in the pathogenesis of these two diseases.