Open AccessGene polymorphisms and chronic obstructive pulmonary disease
Author(s) -
Wu Xiaodan,
Yuan Bowei,
López Elena,
Bai Chunxue,
Wang Xiangdong
Publication year - 2014
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12159
Subject(s) - copd , genetic association , disease , pulmonary disease , medicine , genome wide association study , etiology , gene , phenotype , genetics , bioinformatics , biology , genotype , single nucleotide polymorphism
The genetic component was suggested to contribute to the development of chronic obstructive pulmonary disease ( COPD ), a major and growing public health burden. The present review aims to characterize the evidence that gene polymorphisms contribute to the aetiology of COPD and related traits, and explore the potential relationship between certain gene polymorphisms and COPD susceptibility, severity, lung function, phenotypes, or drug effects, even though limited results from related studies lacked consistency. Most of these studies were association studies, rather than confirmatory studies. More large‐sized and strictly controlled studies are needed to prove the relationship between gene polymorphisms and the reviewed traits. More importantly, prospective confirmatory studies beyond initial association studies will be necessary to evaluate true relationships between gene polymorphisms and COPD and help individualized treatment for patients with COPD .