Open AccessTelocytes in human oesophagus
Author(s) -
Chen Xiaoke,
Zheng Yonghua,
Manole Catalin G.,
Wang Xiangdong,
Wang Qun
Publication year - 2013
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12149
Subject(s) - lamina propria , submucosa , stromal cell , immunohistochemistry , pathology , biology , muscular layer , anatomy , microbiology and biotechnology , epithelium , medicine
Telocytes ( TC s), a new type of interstitial cells, were identified in many different organs and tissues of mammalians and humans. In this study, we show the presence, in human oesophagus, of cells having the typical features of TC s in lamina propria of the mucosa, as well as in muscular layers. We used transmission electron microscopy ( TEM ), immunohistochemistry ( IHC ) and primary cell culture. Human oesophageal TC s present a small cell body with 2–3 very long Telopodes (Tps). Tps consist of an alternation of thin segments ( podomers ) and thick segments ( podoms ) and have a labyrinthine spatial arrangement. Tps establish close contacts (‘stromal synapses’) with other neighbouring cells ( e.g . lymphocytes, macrophages). The ELISA testing of the supernatant of primary culture of TC s indicated that the concentrations of VEGF and EGF increased progressively. In conclusion, our study shows the existence of typical TC s at the level of oesophagus (mucosa, submucosa and muscular layer) and suggests their possible role in tissue repair.