Open AccessCancer, stem cell misplacement and cancer stem cells
Author(s) -
Liao Yong
Publication year - 2013
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12104
Subject(s) - carcinogenesis , cancer stem cell , stem cell , cancer , somatic cell , cancer research , cell of origin , breast cancer , biology , cancer cell , medicine , genetics , gene
Abstract The cell of origin of cancer as well as cancer stem cells is still a mystery. In a recent issue of JCMM , Wang et al . challenged the conventional somatic genetic mutation model of multi‐stage carcinogenesis of breast cancer and proposed that ‘Invasive cancers are not necessary from preformed in situ tumours—an alternative way of carcinogenesis from misplaced stem cells’. If this stem cell misplacement theory could withstand future experimental evaluation, it may provide a paradigm shift in the prevention and management of cancer in the clinic.