Open AccessAssociation between a rare novel TP 53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non‐Hispanic Whites
Author(s) -
Guan Xiaoxiang,
Wang LiE,
Liu Zhensheng,
Sturgis Erich M,
Wei Qingyi
Publication year - 2013
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12076
Subject(s) - lung cancer , melanoma , oncology , head and neck squamous cell carcinoma , genotype , medicine , single nucleotide polymorphism , case control study , cancer , head and neck cancer , allele , snp , cancer research , biology , genetics , gene
Recently, several studies have investigated the association between a newly reported rare functional single nucleotide polymorphism ( SNP ) in TP 53 (rs78378222) and cancer risk, but generated inconsistent findings. The present study further investigated this association with risk of melanoma, squamous cell carcinoma of head and neck ( SCCHN ) and lung cancer. Using volunteers of non‐Hispanic Whites recruited for three large case–control studies, we genotyped the TP 53 rs78378222 SNP in 1329 patients with melanoma, 1096 with SCCHN , 1013 with lung cancer and 3000 cancer‐free controls. Overall, we did not observe any variant homozygotes in this study population, nor significant associations between the TP 53 rs78378222 AC genotype or C allele and risk for melanoma ( P = 0.680 and 0.682 respectively) and lung cancer ( P = 0.379 and 0.382 respectively), but a protection against SCCHN ( P = 0.008 and 0.008 respectively), compared with the AA genotype or A allele. An additional meta‐analysis including 19,423 cancer patients and 54,050 controls did not support such a risk association either. Our studies did not provide statistical evidence of an association between this rare TP 53 variant and increased risk of melanoma, nor of lung cancer, but a possible protection against SCCHN .