Open AccessMechanobiology in cardiac physiology and diseases
Author(s) -
Takahashi Ken,
Kakimoto Yoshihide,
Toda Kensaku,
Naruse Keiji
Publication year - 2013
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12027
Subject(s) - mechanosensitive channels , mechanobiology , mechanotransduction , cardiovascular physiology , piezo1 , cell physiology , mammalian heart , frank–starling law of the heart , mechanosensation , ion channel , neuroscience , physiology , human physiology , medicine , biology , anatomy , heart rate , stroke volume , genetics , receptor , cell , blood pressure
Abstract Mechanosensitivity is essential for heart function just as for all other cells and organs in the body, and it is involved in both normal physiology and diseases processes of the cardiovascular system. In this review, we have outlined the relationship between mechanosensitivity and heart physiology, including the Frank–Starling law of the heart and mechanoelectric feedback. We then focused on molecules involved in mechanotransduction, particularly mechanosensitive ion channels. We have also discussed the involvement of mechanosensitivity in heart diseases, such as arrhythmias, hypertrophy and ischaemic heart disease. Finally, mechanobiology in cardiogenesis is described with regard to regenerative medicine.