Open AccessImpact of home blood pressure variability on cardiovascular outcome in patients with arterial stiffness: Results of the J‐HOP study
Author(s) -
Ishiyama Yusuke,
Hoshide Satoshi,
Kanegae Hiroshi,
Kario Kazuomi
Publication year - 2021
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.14327
Subject(s) - medicine , arterial stiffness , hazard ratio , blood pressure , quartile , pulse wave velocity , cardiology , confidence interval , proportional hazards model , population , pulse pressure , morning , risk factor , environmental health
This study sought to investigate whether the relation between increased blood pressure (BP) variability and increased arterial stiffness confers a risk for cardiovascular disease (CVD) events. We analyzed 2648 patients from a practitioner‐based population (mean ± SD age 64.9 ± 11.4 years: 75.8% taking antihypertensive medication) with at least one cardiovascular risk factor who underwent home BP monitoring in the Japan Morning Surge‐Home Blood Pressure Study. The standard deviation (SD SBP ), coefficient of variation (CV SBP ), and average real variability (ARV SBP ) were assessed as indexes of day‐by‐day home systolic BP (SBP) variability. The authors assessed arterial stiffness by brachial‐ankle pulse wave velocity (baPWV) and divided patients into lower (< 1800 cm/s, n = 1837) and higher (≥1800 cm/s, n = 811) baPWV groups. During a mean follow‐up of 4.4 years, 95 cardiovascular events occurred (8.1 per 1000 person‐years). In Cox proportional hazard models adjusted for traditional cardiovascular risk factors including average home SBP, the highest quartiles of SD SBP (hazard ratio [HR], 2.30; 95% confidence interval [CI], 1.23‐4.32), CV SBP (HR, 2.89; 95%CI, 1.59‐5.26) and ARV SBP (HR, 2.55; 95%CI, 1.37‐4.75) were predictive of CVD events compared to the other quartiles in the higher baPWV group. Moreover, 1SD increases in SD SBP (HR, 1.44; 95%CI, 1.13‐1.82), CV SBP (HR, 1.49; 95%CI, 1.16‐1.90) and ARV SBP (HR, 1.37; 95%CI, 1.09‐1.73) were also predictive of CVD events. These associations remained even after N‐terminal pro‐brain natriuretic peptide was added to the models. However, these associations were not observed in the lower baPWV group. We conclude that arterial stiffness contributes to the association between home BP variability and CVD incidence.