Open AccessEvaluation of serum calcium differences in hypertensive crises and control patients: A randomly matched case‐control study
Author(s) -
Onor IfeanyiChukwu O.,
Duchane Rose M.,
Payne Casey J.,
Lambert Hannah Naquin,
Mitchner DeMaurian M.,
Beyl Robbie A.,
Nguyen Anh T.,
Bilbe Sarah E.,
White Andrea Arriaga,
Johnson Mariah W.,
Faciane Amber I.,
Kouagou Emmanuel,
Hymel Stephanie A.,
Wates Bria M.,
Sanders Asia D.,
Vo Phillip C. B.,
Bates Jordan D.,
Spooner Raven J.,
Gillard Christopher J.,
Okogbaa John I.,
Sarpong Daniel F.,
Hadgu Rim M.,
Okpechi Samuel C.,
Onor Gabriel I.,
Okoronkwo Michael C.,
Naljayan Mihran V.,
Guillory Shane G.,
Sanne Shane E.
Publication year - 2021
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.14268
Subject(s) - medicine , calcium , blood pressure , case control study , diabetes mellitus , observational study , body mass index , endocrinology
The role of calcium in blood pressure has been widely studied among hypertensive patients; however, no study has explored the role of calcium in hypertensive crises. The primary objective of this study is to evaluate the differences in serum calcium levels between hypertensive crises patients and a 1:1 random matched controls (age‐, sex‐, race‐, diabetes, and body mass index matched). This study is a single‐center, retrospective, chart review, case‐control study of patients with hypertensive crises (case group) and patients without hypertensive crises (control group). Patients were included in the case group if they were 18 years of age or older with hypertensive crises and have a documented calcium level. The control group patients were required to be 18 years of age or older, have a documented calcium level, and have no diagnosis of hypertensive crises. The primary outcome of the study was to compare the mean serum calcium in patients with hypertensive crises vs patients without hypertensive crises. Five hundred and sixty‐six patients were included in the study: 283 patients in both the case group and control group. The primary outcome results showed that serum calcium concentration was not significantly different between the case group (8.99 ± 0.78 mg/dL) and control group (8.96 ± 0.75 mg/dL) ( P = .606). This study found no significant difference in serum calcium levels in patients with hypertensive crises compared to a random matched control group. Larger observational or experimental studies may be useful to evaluate the effect of calcium on blood pressure in hypertensive crises.