Open AccessAssociation between serum albumin and peripheral arterial disease in hypertensive patients
Author(s) -
Ding Congcong,
Wang Hua,
Huang Xiao,
Hu Lihua,
Shi Yumeng,
Li Minghui,
Yu Yu,
Zhou Wei,
Wang Tao,
Zhu Lingjuan,
Bao Huihui,
Cheng Xiaoshu
Publication year - 2020
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.14071
Subject(s) - medicine , albumin , odds ratio , serum albumin , arterial disease , gastroenterology , peripheral , confidence interval , vascular disease
Abstract The authors aimed to evaluate the relationship of serum albumin with peripheral arterial disease (PAD) and investigate any possible effect modifiers in hypertensive patients. In the cross‐sectional study, a total of 10,900 Chinese hypertensive patients aged ≥18 years were enrolled. The outcome was PAD, defined as an ankle‐brachial index (ABI) <0.90 in either leg. The overall mean (SD) serum albumin was 46.8 (4.2) g/L. There were significant inverse associations of serum albumin with PAD (per SD increment; OR: 0.83; 95% CI: 0.72, 0.94). Compared with the lowest tertile (<45.1 g/L), the multivariate‐adjusted ORs (95% CI) for participants in the middle tertile (45.1‐48.2 g/L) and highest tertile (≥48.2 g/L) of serum albumin were 0.89 (95% CI: 0.67, 1.16) and 0.65 (95% CI: 0.47, 0.90), respectively. Conversely, lower albumin (<48.2 g/L) concentrations were associated with increased odds of PAD (OR: 1.45; 95% CI: 1.08‐1.96) compared with higher concentrations. Furthermore, the albumin–PAD association was significantly stronger in males (OR: 2.08; 95% CI: 1.31, 3.30) than in females (OR: 1.06; 95% CI: 0.70, 1.58; p interaction = .024). In conclusion, among Chinese hypertensive adults, lower serum albumin was associated with the prevalence of PAD only in males but not in females.