Open AccessBody fat change and 8‐year incidence of hypertension: Korean Genome and Epidemiology Study
Author(s) -
Lee SungBum,
Cho ARa,
Kwon YuJin,
Jung DongHyuk
Publication year - 2019
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13723
Subject(s) - medicine , quartile , body mass index , poisson regression , incidence (geometry) , relative risk , epidemiology , cohort study , risk factor , cohort , demography , confidence interval , population , environmental health , physics , sociology , optics
Hypertension is strongly correlated with an increased risk of cardiovascular events. Recent studies have demonstrated that body fat percentage (BF%) is associated with cardiometabolic risk factors. The aim of this study was to investigate the association between a change in BF% and body mass index (BMI) and the incidence of new‐onset hypertension in a normotensive Korean cohort. At baseline (2001‐2002), 8848 participants aged 40‐70 years were recruited for the study; follow‐up surveys were completed in the year 2012. A total of 3902 adults (1866 men and 2036 women) were included in the final analysis. These subjects were divided into quartile groups according to changes in BF% and were followed for 8.4 years to monitor for the development of hypertension. A Poisson regression model was used to evaluate the relative risk (RR) for hypertension according to BF% change quartile. Additionally, we also stratified participants into four groups according to BMI change levels and body fat change levels. Finally, we compared two factors, BF% change, and BMI change, to determine which is more predictive of incident hypertension. In an adjusted model, compared with the lowest BF% quartile group, the risk of new‐onset hypertension significantly increased with BF% change: Changes in risk were 0%‐2.0% for quartile 3 subjects (RR: 1.32 [1.06‐1.63]) and 2.0%‐8.9% for quartile 4 participants (RR: 1.78 [1.43‐2.19]). We also revealed that the RR for new‐onset hypertension was 1.81 (95% CI: 1.47‐2.21) for quartile 4 group subjects, compared with subjects in quartile 1 (change in BMI −6.80 to −0.86% [kg/m 2 ]). Body fat gain and BMI increase were predictors of hypertension in this community‐based Korean cohort.