Open AccessHypertension‐induced subclinical vascular and cognitive changes are reversible—An observational cohort study
Author(s) -
CzurigaKovács Katalin Réka,
Szekeres Csilla Cecília,
Bajkó Zoltán,
Csapó Krisztina,
Oláh László,
Magyar Mária Tünde,
Molnár Sándor,
Czuriga Dániel,
Kardos László,
Bojtor Burainé Andrea,
Bereczki Dániel,
Soltész Pál,
Csiba László
Publication year - 2019
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13537
Subject(s) - medicine , pulse wave velocity , subclinical infection , hemodynamics , cardiology , arterial stiffness , ambulatory , blood pressure , ambulatory blood pressure , tilt table test , anxiety , cohort , pulse pressure , heart rate , psychiatry
Abstract Beside the well‐known complications of poorly controlled, long‐standing hypertension, milder abnormalities induced by early‐stage hypertension have also been described. In our study, the authors examined the reversibility of changes induced by early‐stage hypertension. The authors performed laboratory testing, ambulatory blood pressure monitoring, carotid intima‐media thickness (IMT) measurement, evaluation of stiffness parameters, assessment of various cardiac and cerebral hemodynamic parameters during head‐up tilt table (HUTT) testing, and neuropsychological examinations in 49 recently diagnosed hypertensive patients. Following baseline assessment, antihypertensive therapy was commenced. After one year of therapy, lower IMT values were found. Pulse wave velocity showed a borderline significant decrease. During HUTT, several hemodynamic parameters improved. The patients performed better on neuropsychological testing and reached significantly lower scores on questionnaires evaluating anxiety. The present study shows that early vascular changes and altered cognitive function observed in newly diagnosed hypertensive patients may improve with promptly initiated antihypertensive management.