Open AccessAssociation of P wave peak time with left ventricular end‐diastolic pressure in patients with hypertension
Author(s) -
Burak Cengiz,
Çağdaş Metin,
Rencüzoğulları Ibrahim,
Karabağ Yavuz,
Artaç Inanç,
Yesin Mahmut,
Çınar Tufan,
Yıldız Ibrahim,
Suleymanoglu Muhammed,
Tanboğa Halil Ibrahim
Publication year - 2019
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13530
Subject(s) - preload , medicine , cardiology , receiver operating characteristic , coronary artery disease , diastole , blood pressure , area under the curve , coronary angiography , lead (geology) , ventricular pressure , hemodynamics , myocardial infarction , geomorphology , geology
Left ventricular diastolic dysfunction (LVDD) is commonly seen in hypertensive patients, and it is associated with increased morbidity and mortality. Hence, the detection of LVDD with a simple, inexpensive, and easy‐to‐obtain method can contribute to improving patient prognosis. Therefore, we aimed to evaluate whether there was any association between the electrocardiographic P wave peak time (PWPT) and invasively measured left ventricular end‐diastolic pressure (LVEDP) in hypertensive patients who had undergone coronary angiography following preliminary diagnosis of coronary artery disease. A total of 78 patients were included in this cross‐sectional study. The PWPT was defined as the time from the beginning of the P wave to its peak, and it was calculated from the leads D II and V I . In all patients, LVEDP was measured in steady state. The PWPT in lead D II was significantly longer in patients with high LVEDP; however, there was no significant difference between groups in terms of PWPT in the lead V I . In multivariable analysis, PWPT in lead D II was found to be independent predictor of increased LVEDP (OR: 1.257, 95% CI: 1.094‐1.445; P = 0.001). In receiver operating characteristic curve analysis, the optimal cut‐off value of PWPT in the lead D II for prediction of elevated LVEDP was 64.8 ms, with a sensitivity of 68.7% and a specificity of 91.3% (area under curve: 0.882, 95% CI: 0.789‐0.944, P < 0.001). In conclusion, this study result suggested that prolonged PWPT in the lead D II may be an independent predictor of increased LVEDP among hypertensive patients.