Open AccessThe relationship of renal function to segmental vascular stiffness, ankle‐brachial index, and peripheral artery disease
Author(s) -
Lin YuehHung,
Sung KuoTzu,
Tsai ChengTing,
Wu PeiChen,
Lai YauHuei,
Lo ChiIn,
Yu FaChang,
Wu HsuPing,
Lan WeiRan,
Kuo JenYuan,
Hou Charles JiaYin,
Yen ChiHsuan,
Peng MingCheng,
Hung TaChuan,
Hung ChungLieh,
Lai Edward,
Yeh HungI
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13297
Subject(s) - medicine , cardiology , pulse wave velocity , arterial stiffness , brachial artery , ankle , peripheral , renal function , blood pressure , surgery
The authors consecutively assessed various arterial pulse‐wave velocity ( PWV ) indices and ankle‐brachial index ( ABI ) by an automatic device (VP2000, OMRON Health Care Co. Ltd., Kyota, Japan) in outpatients with ≥ 1 cardiovascular risk. PAD was defined as ABI ≤ 0.9. Among 2309 outpatients (mean age 62.4 years), worse renal function was associated with higher brachial‐ankle PWV , heart‐carotid PWV , heart‐femoral PWV (hf‐ PWV ), and lower ABI (all P < .001). Multivariate regression models showed independent associations between lower eGFR , lower ABI (Coef: 0.42 & 0.41 for right and left), higher hf‐ PWV (Coef: −11.4 [95% CI : −15.4, −7.3]) and greater PAD risk (adjusted OR : 0.83 [95% CI : 0.76, 0.91], all P < .05). eGFR set at 77 mL /min/1.73m 2 was observed to be useful clinical cutoff (c‐statistics: 0.67) for identifying PAD ( P for Δ AUROC : .009; likelihood X 2 : 93.82 to 137.43, P < .001) when superimposed on clinical risks. This study suggested early renal insufficiency is tightly linked to region‐specific vascular stiffness and PAD.