Open AccessReference intervals and percentiles for carotid‐femoral pulse wave velocity in a healthy population aged between 9 and 87 years
Author(s) -
Diaz Alejandro,
Zócalo Yanina,
Bia Daniel,
Wray Sandra,
Fischer Edmundo Cabrera
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13251
Subject(s) - percentile , medicine , pulse wave velocity , cohort , population , standard deviation , demography , blood pressure , cardiology , mathematics , statistics , environmental health , sociology
There is little information regarding age‐related reference intervals ( RI s) of carotid‐femoral pulse wave velocity (cf PWV ) for large healthy populations in South America. The aims of this study were to determine cf PWV RI s and percentiles in a cohort of healthy children, adolescents, and adults and to generate year‐to‐year percentile curves and body‐height percentile curves for children and adolescents. cf PWV was measured in 1722 healthy participants with no cardiovascular risk factors (9–87 years, 60% men). First, RI s were evaluated for males and females through correlation and covariate analysis. Then, mean and standard deviation age‐related equations were obtained for cf PWV using parametric regression methods based on fractional polynomials and age‐specific (year‐to‐year) percentile curves that were defined using the standard normal distribution. Age‐specific first, 2.5th, 5th, 10th, 25th, 50th, 75th, 90th, 95th, 97.5th, and 99th percentile curves were calculated. Finally, height‐related cf PWV percentile curves for children and adolescents (<21 years) were established. After adjusting for age and blood pressure differences with respect to females, males showed higher cf PWV levels (6.60 vs 6.45 m/s; P < .01). Thus, specific RI s for males and females were reported. The study provides the largest database to date concerning cf PWV in healthy people from Argentina. Specific RI s and percentiles of cf PWV are now available according to age and sex. Specific percentiles of cf PWV according to body height were reported for people younger than 21 years.