Open AccessAssociation between serum total homocysteine and arterial stiffness in adults: a community‐based study
Author(s) -
Chen Lulu,
Wang Binyan,
Wang Jiancheng,
Ban Qianyun,
Wu Hongxu,
Song Yun,
Zhang Jingping,
Cao Jingjing,
Zhou Ziyi,
Liu Lishun,
Cao Tianyu,
Gao Lan,
Guo Huiyuan,
Zhang Tao,
Tang Genfu,
Huang Xiao,
Zhang Yan,
Li Jianping,
Huo Yong,
Cheng Xiaoshu,
Zang Tonghua,
Xu Xiping,
Zhang Hao,
Qin Xianhui
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13246
Subject(s) - medicine , arterial stiffness , homocysteine , association (psychology) , cardiology , plasma homocysteine , blood pressure , philosophy , epistemology
Both increased arterial stiffness and higher total homocysteine ( tH cy) are associated with an elevated risk for cardiovascular disease. However, the relationship between tH cy and arterial stiffness is still inconclusive. The authors aimed to test the relationship of tH cy with carotid‐femoral pulse wave velocity (cf PWV ) and examine the possible effect modifiers in adults. A study was conducted from July to September 2016 in Jiangsu Province, China. A total of 16 644 participants were enrolled in the final analysis. Increased arterial stiffness is defined as a cf PWV ≥10 m/s. Overall, there was a positive association between tH cy and cf PWV levels (per 5‐μmol/L tH cy increase: β = 0.10; 95% confidence interval [CI], 0.08–0.13) and increased arterial stiffness (per 5‐μmol/L tH cy increase: odds ratio, 1.11; 95% CI, 1.07–1.14). Compared with participants with tH cy <10 μmol/L, the significantly higher cf PWV levels were observed in those with tH cy ≥15 μmol/L (β = 0.37; 95% CI, 0.28–0.47). Accordingly, a higher prevalence of increased arterial stiffness was found in patients with tH cy10 to <15 μmol/L ( odds ratio, 1.18; 95% CI, 1.05–1.33) and tH cy ≥15 μmol/L ( odds ratio, 1.50; 95% CI, 1.32–1.71) as compared with participants with tH cy <10 μmol/L. Furthermore, the stronger positive association was found in participants who were older (≥60 years, P for interaction = .008), had low body mass index (<25 kg/m 2 , P for interaction = .026), high systolic blood pressure levels (≥145 mm Hg [median], P for interaction = .048), or diabetes mellitus ( P for interaction = .045). The present study demonstrated that serum tH cy concentrations were positively associated with cf PWV and the prevalence of increased arterial stiffness. These results suggest that the cardiovascular effects of tH cy may partly be mediated through arterial stiffness.