Open AccessRelation of uric acid level to rapid kidney function decline and development of kidney disease: The Jackson Heart Study
Author(s) -
Mwasongwe Stanford E.,
Fülöp Tibor,
Katz Ronit,
Musani Solomon K.,
Sims Mario,
Correa Adolfo,
Flessner Michael F.,
Young Bessie A.
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13239
Subject(s) - kidney disease , quartile , medicine , renal function , uric acid , odds ratio , risk factor , cardiology , confidence interval
Whether elevated uric acid ( UA ) is an independent risk factor for chronic kidney disease ( CKD ) is not well established. The authors evaluated the relationship of UA with rapid kidney function decline ( RKFD ) and incident CKD among 3702 African Americans ( AA s) in the Jackson Heart Study with serum UA levels measured at baseline exam (2000‐2004). RKFD was defined as ≥ 30% eGFR loss and incident CKD as development of eGFR < 60 mL /min/1.73 m 2 with a ≥ 25% decline in eGFR between baseline and exam 3 (2009‐2013). RKFD and CKD were found in 11.4% and 7.5% of the participants, respectively. In a fully adjusted model, the odds of RKFD ( OR , 1.8; 95% CI , 1.25‐2.49) and incident CKD ( OR , 2.00; 95% CI , 1.31‐3.06) were significantly higher among participants in the top UA quartile vs bottom quartile. In the JHS , elevated UA was significantly associated with RKFD and incident CKD.