Open AccessExaggerated blood pressure variability is associated with memory impairment in very elderly patients
Author(s) -
Fujiwara Takeshi,
Hoshide Satoshi,
Kanegae Hiroshi,
Eguchi Kazuo,
Kario Kazuomi
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13231
Subject(s) - medicine , blood pressure , quartile , confidence interval , ambulatory blood pressure , ambulatory , odds ratio , cohort , pediatrics , cardiology
We investigated the association between working memory ( WM ) impairment and blood pressure variability ( BPV ) in very elderly patients. Japanese outpatients ≥80 years who engaged in normal activities of daily living were the study cohort. WM function was evaluated by a simple visual WM test consisting of 3 figures. We considered the number of figures recalled by the patient his/her test score. We defined the patients with a score of 0 or 1 as those with WM impairment and those with scores of 2 or 3 as those without. To investigate the relative risk of WM impairment, we evaluated each patient's 24 hour ambulatory systolic blood pressure ( SBP ) and its weighted standard deviation ( SD SBP ), office SBP , and the visit‐to‐visit SD SBP during the 1 year period from the patient's enrollment. A total of 66 patients (mean 84 ± 3.6 years) showed WM impairment, and 431 patients (mean 83 ± 3.1 years) showed no WM impairment. There were no significant differences in 24 hour ambulatory SBP or office SBP between these two groups. However, the WM impairment patients showed significantly higher weighted SD SBP and visit‐to‐visit SD SBP values compared to the no‐impairment group even after adjusting for age. Among these ≥80‐year‐old patients, those with the highest quartile of both weighted SD SBP (≥21.4 mm Hg) and visit‐to‐visit SD SBP (≥14.5 mm Hg) showed the highest relative risk (odds ratio 3.52, 95% confidence interval 1.42‐8.72) for WM impairment. Exaggerated blood pressure variability parameters were significantly associated with working memory impairment in very elderly individuals.