Open Access24‐hour aortic blood pressure variability showed a stronger association with carotid damage than 24‐hour brachial blood pressure variability: The SAFAR study
Author(s) -
Yu Shikai,
Chi Chen,
Protogerou Athanase D.,
Safar Michel E.,
Blacher Jacques,
Argyris Antonis A.,
Nasothimiou Efthimia G.,
Sfikakis Petros P.,
Papaioannou Theodore G.,
Xu Henry,
Zhang Yi,
Xu Yawei
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13226
Subject(s) - medicine , percentile , cardiology , blood pressure , ambulatory blood pressure , brachial artery , intima media thickness , carotid arteries , statistics , mathematics
We aim to compare 24‐hour aortic blood pressure variability ( BPV ) with brachial BPV in relation to carotid damage as estimated by carotid intima‐media thickness ( CIMT ) and cross‐sectional area ( CCSA ). Four hundred and forty five individuals received brachial and aortic 24‐hour ambulatory BP monitoring with a validated device (Mobil‐O‐Graph). Systolic BPV was estimated by average real variability ( ARV ) and time‐weighted standard deviation (w SD ). In multiple logistic regression analysis, CIMT > 900 μm was significantly and independently associated with aortic ARV ( OR = 1.38; 95% CI : 1.04‐1.84), aortic w SD ( OR = 1.65; 95% CI : 1.19‐2.29) and brachial ARV ( OR = 1.53; 95% CI : 1.07‐2.18), but not with brachial w SD . CCSA > 90th percentile was significantly and independently associated with aortic ARV ( OR = 1.50; 95% CI : 1.07‐2.10) and w SD ( OR = 1.70; 95% CI : 1.12‐2.56), but not with brachial BPV s. In receiver operator characteristics curve analysis, aortic w SD identified CCSA > 90th percentile better than brachial w SD ( AUC : 0.73 vs 0.68, P < .01). In conclusion, aortic 24‐hour systolic BPV showed a slightly stronger association with carotid damage than brachial BPV.