Open AccessGenetic factors contributing to hypertension in African‐based populations: A systematic review and meta‐analysis
Author(s) -
Yako Yandiswa Y.,
Balti Eric V.,
Matsha Tandi E.,
Dzudie Anastase,
Kruger Deirdre,
Sobngwi Eugene,
Agyemang Charles,
Kengne Andre P.
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13225
Subject(s) - meta analysis , odds ratio , confidence interval , genetic model , single nucleotide polymorphism , allele , essential hypertension , polymorphism (computer science) , genetic association , medicine , blood pressure , genetics , biology , bioinformatics , genotype , gene
In a systematic review, the authors explored genetic association studies of essential hypertension in African populations. Studies reporting on the association of polymorphism(s) with hypertension in African populations were included. Appropriate studies were pooled using random effects model meta‐analysis, under six potential inheritance models. In all, 46 polymorphisms in 33 genes were investigated for their association with hypertension or blood pressure levels. Meta‐analysis was possible for three single nucleotide polymorphisms: rs4340, rs699, and rs5186. An association was found between rs5186, rs699, and hypertension under allele contrast and homozygous codominant models (odds ratio, 1.63 [95% confidence interval, 1.04–2.54] and 4.01 [95% confidence interval, 1.17–13.80] for rs5186, respectively; and 1.80 [95% confidence interval, 1.13–2.87] for rs699). Findings were mostly robust in sensitivity analyses. According to the systematic review, there is currently insufficient evidence on the specific polymorphisms that pose the risk of hypertension in African populations. Large‐scale genetic studies are warranted to better understand susceptibility polymorphisms that may be specific to African populations.