Open AccessArterial stiffness and subendocardial viability ratio in patients with peripheral arterial disease
Author(s) -
Scandale Giovanni,
Dimitrov Gabriel,
Recchia Martino,
Carzaniga Gianni,
Minola Marzio,
Perilli Edoardo,
Carotta Maria,
Catalano Mariella
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13213
Subject(s) - medicine , cardiology , arterial stiffness , peripheral , ankle , pulse wave velocity , perfusion , applanation tonometry , arterial disease , blood pressure , vascular disease , surgery
Arterial stiffening is a hallmark of the aging process and atherosclerosis, including peripheral arterial disease ( PAD ). We investigated the associations between carotid‐femoral pulse wave velocity (c‐ fPWV ), augmentation index corrected for heart rate (Aix@ HR 75), ankle brachial index ( ABI ), and subendocardial viability ratio ( SEVR ), an indicator of cardiac perfusion. The c‐ fPWV , Aix@ HR 75, and SEVR was estimated using applanation tonometry. The ankle systolic pressure measurements for the calculation of the ABI were obtained using an 8‐ mH z Doppler probe. The study group included 555 subjects, mean age 63 ± 11 years (248 PAD ( ABI < 1.0), and 307 non‐ PAD ( ABI ≥ 1.0 ≤ 1.3). After the stepwise selection process in both PAD and non‐ PAD patients SEVR was not related to c‐ fPWV and ABI ( P = .154; P = .156) and ( P = .101; P = .402), respectively. In PAD patients, SEVR was negatively related to Aix@ HR 75 ( P < .0001) and aortic PP ( P = .0005). In conclusion, arterial stiffness is associated with non‐invasive indices of myocardial perfusion in PAD patients, suggesting a potential pathophysiological link for increased cardiovascular events.