Open AccessSerum uric acid is associated with incidence of heart failure with preserved ejection fraction and cardiovascular events in patients with arterial hypertension
Author(s) -
Gu Jun,
Fan YuQi,
Zhang HuiLi,
Zhang JunFeng,
Wang ChangQian
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13210
Subject(s) - medicine , cardiology , ejection fraction , hyperuricemia , heart failure , left ventricular hypertrophy , heart failure with preserved ejection fraction , uric acid , incidence (geometry) , diastole , diastolic heart failure , blood pressure , physics , optics
The objective of the present study was to evaluate clinical implications of serum uric acid ( UA ) on the progression of heart failure with preserved ejection fraction ( HF p EF ) in hypertensive patients. A total of 1009 adult patients with left ventricular hypertrophy and suspected left ventricular diastolic dysfunction were enrolled at our hospital from January 2008 to December 2011. With a median follow‐up of 7.2 years, 136 (13.2%) patients developed new‐onset HF p EF and 151 (15.0%) had major adverse cardiovascular events ( MACE s). Compared with the lowest UA tertile of UA (<302 μmol L −1 ), subjects in the highest tertile (>367 μmol L −1 ) had a higher risk of developing new‐onset HF p EF ( HR : 1.761, 95% CI : 1.119‐2.772, P = .015) as well as MACE s ( HR : 1.664, 95% CI : 1.086‐2.547, P = .019). Our findings indicate that hyperuricemia is associated with detrimental effects in terms of the incidence of new‐onset HF p EF as well as MACE s in hypertensive patient.