Open AccessAssociation of visit‐to‐visit blood pressure variability with the risk of all‐cause mortality and cardiovascular events in general population
Author(s) -
Dai Liye,
Song Lu,
Li Xiaoli,
Yang Yuling,
Zheng Xiaoming,
Wu Yuntao,
Li Chunhui,
Zhao Hualing,
Wang Yilong,
Wu Shouling,
Wang Yongjun
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13192
Subject(s) - hazard ratio , medicine , quartile , blood pressure , confounding , proportional hazards model , confidence interval , cardiology , cause of death , prospective cohort study , population , regression dilution , cohort , cohort study , disease , regression analysis , environmental health , bayesian multivariate linear regression , machine learning , computer science
The association between blood pressure variability ( BPV ) and the risk of all‐cause mortality and cardiovascular diseases ( CVD ) is not well understood. The Kailuan study is a prospective longitudinal cohort study on cerebrovascular events and cardiovascular factors. In this study, resting blood pressure was measured at baseline and every 2 years from 2006 to 2007. BPV is mainly defined as the coefficient of variation ( CV ). Hazard ratio ( HR ), with 95% confidence intervals ( CI ) was calculated using Cox regression model. Among 52 387 participants, we identified 1817 who ended up with all‐cause death and 1198 with CVD . Each 4.68% increase in BPV was associated with a 13% increase in the risk of mortality ( HR = 1.13, 95% CI = 1.09‐1.18) and a 7% increase in CVD ( HR = 1.07, 95% CI = 1.02‐1.13), respectively. After adjustment of confounding factors, the HR of comparing participants in the highest versus lowest quartile of CV of systolic blood pressure ( SBP ) was 1.37 (1.19, 1.57) for all‐cause death, 1.18 (1.01, 1.39) for CVD . Similar results were also observed when BPV was measured by different parameters. We concluded that visit‐to‐visit BPV was associated with all‐cause death and cardiovascular and cerebrovascular events in Chinese general population.