Open AccessCentral blood pressure variability is increased in hypertensive patients with target organ damage
Author(s) -
de la Sierra Alejandro,
Pareja Julia,
Yun Sergi,
Acosta Eva,
Aiello Francesco,
Oliveras Anna,
Vázquez Susana,
Armario Pedro,
Blanch Pedro,
Sierra Cristina,
Calero Francesca,
FernándezLlama Patricia
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13172
Subject(s) - medicine , cardiology , blood pressure , pulse wave velocity , left ventricular hypertrophy , microalbuminuria , ambulatory blood pressure , pulse pressure , diastole , brachial artery , ambulatory , heart rate
We aimed to evaluate the association of aortic and brachial short‐term blood pressure variability (BPV) with the presence of target organ damage (TOD) in hypertensive patients. One‐hundred seventy‐eight patients, aged 57 ± 12 years, 33% women were studied. TOD was defined by the presence of left ventricular hypertrophy on echocardiogram, microalbuminuria, reduced glomerular filtration rate, or increased aortic pulse wave velocity. Aortic and brachial BPV was assessed by 24‐hour ambulatory BP monitoring (Mobil‐O‐Graph). TOD was present in 92 patients (51.7%). Compared to those without evidence of TOD, they had increased night‐to‐day ratios of systolic and diastolic BP (both aortic and brachial) and heart rate. They also had significant increased systolic BPV, as measured by both aortic and brachial daytime and 24‐hours standard deviations and coefficients of variation, as well as for average real variability. Circadian patterns and short‐term variability measures were very similar for aortic and brachial BP. We conclude that BPV is increased in hypertensive‐related TOD. Aortic BPV does not add relevant information in comparison to brachial BPV.