Open AccessSex‐related relationships between uric acid and target organ damage in hypertension
Author(s) -
Maloberti Alessandro,
Maggioni Simone,
Occhi Lucia,
Triglione Nicola,
Panzeri Francesco,
Nava Stefano,
Signorini Stefano,
Falbo Rosanna,
Casati Marco,
Grassi Guido,
Giannattasio Cristina
Publication year - 2018
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13136
Subject(s) - medicine , hyperuricemia , renal function , uric acid , blood pressure , cardiology , endocrinology , pulse wave velocity , urology
Heterogeneous results have been obtained in the relationship between serum uric acid ( SUA ) and target organ damage ( TOD ) in patients with hypertension. Clinic blood pressure, SUA , and cardiac, arterial (carotid and aortic), and renal TOD were assessed in 762 consecutive patients with hypertension. Hyperuricemia was defined as an SUA >7.0 in men and >6.0 mg/dL in women. Men with hyperuricemia compared with those with normal SUA showed lower estimated glomerular filtration rates and E/A ratios and a higher prevalence of carotid plaques. Women with hyperuricemia showed lower estimated glomerular filtration rates and E/A ratios and a higher intima‐media thickness. Except for pulse wave velocity, all TOD s significantly correlated with SUA . However, at multivariate analysis, only estimated glomerular filtration rate was significantly determined by SUA . Our data provide evidence on the role of SUA in the development of TOD only in the case of renal alteration. It is likely that SUA may indirectly act on the other TOD s through the increase in blood pressure and the decrease in glomerular filtration rate.