Open AccessSalt intake and blood pressure response to percutaneous renal denervation in resistant hypertension
Author(s) -
Beus Esther,
Jager Rosa L.,
Beeftink Martine M.,
Sanders Margreet F.,
Spiering Wilko,
Vonken EvertJan,
Voskuil Michiel,
Bots Michiel L.,
Blankestijn Peter J.
Publication year - 2017
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13085
Subject(s) - medicine , denervation , blood pressure , resistant hypertension , percutaneous , cardiology
The effect of lowering sympathetic nerve activity by renal denervation ( RDN ) is highly variable. With the exception of office systolic blood pressure ( BP ), predictors of the BP ‐lowering effect have not been identified. Because dietary sodium intake influences sympathetic drive, and, conversely, sympathetic activity influences salt sensitivity in hypertension, we investigated 24‐hour urinary sodium excretion in participants of the SYMPATHY trial. SYMPATHY investigated RDN in patients with resistant hypertension. Both 24‐hour ambulatory and office BP measurements were end points. No relationship was found for baseline sodium excretion and change in BP 6 months after RDN in multivariable‐adjusted regression analysis. Change in the salt intake–measured BP relationships at 6 months vs baseline was used as a measure for salt sensitivity. BP was 8 mm Hg lower with similar salt intake after RDN , suggesting a decrease in salt sensitivity. However, the change was similar in the control group, and thus not attributable to RDN .