Open AccessIndependent association between age and circadian systolic blood pressure patterns in adults with hypertension
Author(s) -
Deng Ming,
Chen DaWei,
Dong YiFei,
Lu Peng,
Zhan BiMing,
Xu JianQing,
Ji XiXin,
Li Ping,
Cheng XiaoShu
Publication year - 2017
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13057
Subject(s) - medicine , blood pressure , circadian rhythm , association (psychology) , cardiology , epistemology , philosophy
Previous studies indicate a preliminary association between age and circadian blood pressure ( BP ) variation. This association would be affected by confounding factors in real‐world populations. The authors investigated whether this is a convincingly independent association in a real‐world population of adults with hypertension. Clinical data and findings of 24‐hour ambulatory BP monitoring were obtained from 297 consecutive adults with hypertension (60.19±0.77 years). BP dipping patterns were categorized based on the percentage of nocturnal BP drop. Multivariate linear regression analysis identified an independent correlation between age and percentage of nocturnal systolic BP drop (β=−7.296; 95% CI , −10.430 to −4.162 [ P <.001]). Reverse dippers were the oldest and extreme dippers were the youngest. A significant age difference was noted among patients grouped into four BP dipping patterns with and without adjustments for sex, body mass index, drugs, diabetes mellitus, smoking, 24‐hour mean heart rate, and 24‐hour mean systolic and diastolic BP .