Open AccessAntialbuminuric effect of eplerenone in comparison to thiazide diuretics in patients with hypertension
Author(s) -
Sawai Toshiki,
Dohi Kaoru,
Fujimoto Naoki,
Okubo Setsuya,
Isaka Naoki,
Ichikawa Takehiko,
Makino Katsutoshi,
Okamoto Shinya,
Koyabu Sukenari,
Kitamura Tetsuya,
Ogura Toru,
Yamada Tomomi,
Tamaru Satoshi,
Nishikawa Masakatsu,
Nakamura Mashio,
Ito Masaaki
Publication year - 2017
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13054
Subject(s) - medicine , eplerenone , thiazide , albuminuria , creatinine , urology , endocrinology , angiotensin receptor , renal function , blood pressure , angiotensin ii , spironolactone , heart failure
This study investigated the effects and safety of eplerenone or thiazide diuretics in patients with hypertension and albuminuria (pretreatment urinary albumin/creatinine ratio ≥10 mg/ gC r) treated with an angiotensin II receptor blocker. The primary end point was the mean percent change in the urinary albumin/creatinine ratio from baseline to 48 weeks. An efficacy analysis was performed in 195 patients (98 in the eplerenone group and 97 in the thiazide group). Systolic and diastolic blood pressures at 48 weeks were similar in the two groups. The mean percent change in the urinary albumin/creatinine ratio from baseline to 48 weeks was similar in the two groups ( P =.804). In the safety analysis, the withdrawal rates for adverse events were similar in both groups. The antialbuminuric effects and safety of eplerenone therapy were similar to those of thiazide diuretics when combined with an angiotensin II receptor blocker in patients with hypertension and albuminuria.