Open AccessUsefulness of fragmented QRS in hypertensive patients in the absence of left ventricular hypertrophy
Author(s) -
Eyuboglu Mehmet,
Karabag Yavuz,
Karakoyun Suleyman,
Senarslan Omer,
Tanriverdi Zulkif,
Akdeniz Bahri
Publication year - 2017
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13051
Subject(s) - medicine , cardiology , left ventricular hypertrophy , blood pressure , ambulatory blood pressure , confounding , receiver operating characteristic , qrs complex , odds ratio , muscle hypertrophy , logistic regression , electrocardiography , ambulatory
In the absence of left ventricular hypertrophy, importance of fragmented QRS complex ( fQRS ) in individuals with hypertension is unknown. The authors aimed to evaluate the relationship between blood pressure levels and fQRS in the absence of left ventricular hypertrophy . A total of 548 never‐treated patients who underwent 24‐hour ambulatory blood pressure monitoring were enrolled. The frequency of fQRS was significantly higher in patients with hypertension than normotension (36.4% vs 17.6%, P <.05). Multivariate logistic regression analysis revealed that systolic blood pressure is significantly associated with presence of fQRS on electrocardiography ( odds ratio, 0.931; 95% CI, 0.910–0.9521 [ P <.001]) even after adjusting for other confounding factors. Receiver operating characteristic analysis revealed a cutoff value of 147.65 mm Hg for systolic blood pressure to predict presence of fQRS (sensitivity: 51%, specificity: 99%, area under the curve=0.764; 95% CI, 0.717–0.811 [ P <.001]). fQRS may be a sign of increased blood pressure and may predict higher fibrotic burden in patients with hypertension.