Open AccessPrognostic value of nighttime blood pressure load in Chinese patients with nondialysis chronic kidney disease
Author(s) -
Li Yan,
Deng Qiongxia,
Li Huiqun,
Ma Xinxin,
Zhang Jun,
Peng Hui,
Wang Cheng,
Lou Tanqi
Publication year - 2017
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13017
Subject(s) - medicine , hazard ratio , kidney disease , proportional hazards model , blood pressure , cardiology , ambulatory blood pressure , confidence interval , cohort , diastole
The prognostic value of nighttime blood pressure ( BP ) load in patients with chronic kidney disease ( CKD ) remains unknown. The prognostic value of nighttime BP load in a cohort of Chinese patients with nondialysis CKD was investigated . The authors monitored ambulatory BP and followed health outcomes in 588 Chinese CKD patients. Multivariable‐adjusted Cox regression analyses indicated that nighttime BP load was a significant risk factor for all clinical outcomes in CKD patients, even when adjusted for clinic BP . Tertile 3 of systolic BP load (vs tertile 1) was associated with an increased risk of renal events (hazard ratio [ HR ], 2.21; 95% confidence interval [ CI ], 1.12–4.38) and cardiovascular events (HR, 5.34; 95% CI, 1.58–18.04); tertile 3 of diastolic BP load (vs tertile 1) was associated with an increased risk of all‐cause mortality (HR, 6.73; 95% CI, 1.79–25.20), cardiovascular mortality (HR, 7.18; 95% CI, 1.47–35.03), renal events (HR, 2.40; 95% CI, 1.17–4.92), and cardiovascular events (HR, 5.87; 95% CI, 1.97–17.52). Higher nighttime BP load, especially nighttime diastolic BP load, was associated with a poorer prognosis in Chinese nondialysis CKD patients.