Open AccessAssociation of obstructive sleep apnea with arterial stiffness and nondipping blood pressure in patients with hypertension
Author(s) -
Jenner Raimundo,
FaturetoBorges Fernanda,
CostaHong Valéria,
Lopes Heno F.,
Teixeira Sandra H.,
Marum Elias,
Giorgi Dante A. M.,
ConsolimColombo Fernanda M.,
Bortolotto Luiz A.,
LorenziFilho Geraldo,
Krieger Eduardo M.,
Drager Luciano F.
Publication year - 2017
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.13008
Subject(s) - medicine , pulse wave velocity , obstructive sleep apnea , blood pressure , cardiology , arterial stiffness , ambulatory blood pressure , polysomnography , odds ratio , confidence interval , diastole , apnea
Whether sex influences the association of obstructive sleep apnea ( OSA ) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid‐femoral pulse wave velocity, 24‐hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30‐day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non‐ OSA patients, pulse wave velocity values were higher in the OSA group (men: 11.1±2.2 vs 12.7±2.4 m/s, P =.04; women: 11.8±2.4 vs 13.2±2.2 m/s, P =.03). The proportion of diastolic dysfunction was significant in men and women with OSA . Compared with non‐OSA patients, nondipping systolic blood pressure in OSA was higher in men (14.3% vs 46.4%) and in women (41.4% vs 65.2%). OSA was independently associated with pulse wave velocity (β=1.050; P =.025) and nondipping systolic blood pressure (odds ratio, 3.03; 95% confidence interval, 1.08–8.55; P =.035) in the regression analysis. In conclusion, OSA is independently associated with arterial stiffness and nondipping blood pressure in patients with hypertension regardless of sex.