Open AccessThe concept of crosstalk‐directed embryological target mining and its application to essential hypertension treatment failures
Author(s) -
Sag Alan Alper,
Sal Oguzhan,
Kilic Yagmur,
Onal Emine Meltem,
Kanbay Mehmet
Publication year - 2017
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12978
Subject(s) - crosstalk , medicine , bioinformatics , intensive care medicine , frontier , computational biology , computer science , data science , neuroscience , biology , physics , optics , history , archaeology
This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug‐resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician‐directed fashion.