Risk factors for preeclampsia in infertile Chinese women with polycystic ovary syndrome: A prospective cohort study

To explore preconception risk factors for preeclampsia ( PE ) in women with polycystic ovary syndrome ( PCOS ), a prospective cohort study was conducted in 92 infertile Chinese women with PCOS who had a singleton pregnancy by ovulation induction and were followed up for 6 weeks after delivery. The patients underwent assessment of physical, endocrine, and metabolic features before ovulation induction. Fifteen (16.3%) patients were diagnosed with PE . Logistic regression analysis showed that preconception sex hormone–binding globulin ( SHBG ), insulin level at 120 minutes, and body mass index were three independent risk factors for PE (odds ratio [ OR ], 0.981; 95% confidence interval [ CI ], 0.964–0.998 [ P =.027]; OR , 1.011; 95% CI , 1.000–1.021 [ P =.048]; and OR , 1.249; 95% CI , 0.992–1.572 [ P =.059], respectively). Receiver operator characteristic analysis indicated the risk value of prepregnancy SHBG , insulin level at 120 minutes, and body mass index (area under the curve=.788, .686, and .697, respectively). Preconception low SHBG levels, overweight/obesity, and hyperinsulinism might be correlated with the subsequent development of PE in patients with PCOS .