Open AccessAtherosclerotic Surrogate Markers in Adults With Down Syndrome: A Case‐Control Study
Author(s) -
Parra Pedro,
Costa Ramón,
Asúa Diego Real,
Moldenhauer Fernando,
Suárez Carmen
Publication year - 2017
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12890
Subject(s) - medicine , arterial stiffness , pulse wave velocity , dyslipidemia , metabolic syndrome , surrogate endpoint , subclinical infection , population , cohort , anthropometry , disease , cardiology , obesity , blood pressure , environmental health
The authors aimed to compare surrogate markers of atherosclerosis (pulse wave velocity, intima‐media thickness) between adults with and without Down syndrome (DS) and to assess the impact of parathyroid hormone levels and classic cardiovascular risk factors on arterial stiffness. After comparing 51 adults with DS and 51 healthy adults (siblings of DS individuals), the authors found that adults with DS seem to have lower arterial stiffness, as a result of chronic hypotension. Subclinical atherosclerosis parameters do not correlate with traditional cardiovascular risk factors in adults with DS , thus raising the hypothesis that classic predictive models for cardiovascular disease are not valid in this population. Hyperparathyroidism could play an important role in arterial damage in these individuals. The lower than expected prevalence of obesity and dyslipidemia could be explained by better eating habits, with this study being the first to address the anthropometric and clinical profile of a Mediterranean cohort of adults with DS.