Open AccessSubclinical Organ Damage in White‐Coat Hypertension: The Possible Role of Cystatin C
Author(s) -
Androulakis Emmanuel,
Papageorgiou Nikolaos,
Lioudaki Eirini,
Chatzistamatiou Evaggelos,
Zacharia Effimia,
Kallikazaros Ioannis,
Tousoulis Dimitris
Publication year - 2017
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12882
Subject(s) - medicine , subclinical infection , cystatin c , white coat hypertension , cardiology , left ventricular hypertrophy , pulse wave velocity , renal function , ambulatory blood pressure , blood pressure
The authors investigated the relationship of white‐coat hypertension ( WCH ) with subclinical organ damage and potential relevant mechanisms. A total of 386 untreated patients were enrolled and divided into 204 patients with WCH and 183 with normotension. Flow‐mediated dilation ( FMD ), pulse wave velocity ( PWV ), intima‐media thickness, left ventricular mass index ( LVMI ), and cystatin C levels were measured. All tests were two‐sided, and a P value <.05 was considered statistically significant. The WCH group exhibited higher LVMI and PWV values, decreased E/A ratio and FMD values, and increased prevalence for left ventricular hypertrophy compared with controls ( P <.001 for all). Cystatin C was significantly higher in the WCH group compared with controls ( P =.035) and was positively associated with LVMI ( P <.05 for both). The presence of WCH is associated with more pronounced subclinical organ damage compared with normotension. Cystatin C may play a significant role and therefore warrants further investigation.