Open AccessSeverity of Alopecia Predicts Coronary Changes and Arterial Stiffness in Untreated Hypertensive Men
Author(s) -
Triantafyllidi Helen,
Grafakos Agis,
Ikonomidis Ignatios,
Pavlidis George,
Trivilou Paraskevi,
Schoinas Antonis,
Lekakis John
Publication year - 2017
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12871
Subject(s) - medicine , cardiology , pulse wave velocity , arterial stiffness , coronary flow reserve , left ventricular hypertrophy , coronary artery disease , pulse pressure , blood pressure
An association between androgenic alopecia ( AGA ), coronary artery disease, and hypertension has been reported in previous epidemiological studies. The authors evaluated the relationship of target organ damage caused by hypertension with AGA in 101 newly diagnosed and untreated hypertension men with mild to moderate AGA ( AGA m ), severe AGA ( AGA s ), and non‐ AGA . Pulse wave velocity ( PWV ), office and 24‐hour pulse pressure ( PP ), carotid intima‐media thickness ( IMT ), left ventricular hypertrophy ( LVH ), coronary flow reserve ( CFR d ), and AGA severity by Hamilton‐Norwood scale were estimated. CFR d was significantly impaired in AGA s patients compared with AGA m ( P =.007) and non‐ AGA patients ( P =.02). No differences were found within groups regarding PWV , PP , IMT , and LVH . AGA severity was related to CFR d (independently) and PP while AGA duration and age of onset were related to CFR d and PP , respectively. The authors conclude that impaired coronary microcirculation and aortic stiffness might precede the appearance of significant stenotic coronary lesions in hypertensive patients with severe AGA . In addition, hypertensive patients with severe and early AGA onset seem to be exposed to an augmented cardiovascular risk.