Open AccessHyperuricemia and the Prognosis of Hypertensive Patients: A Systematic Review and Meta‐Analysis
Author(s) -
Qin Tianqiang,
Zhou Xiaoqin,
Wang Ji,
Wu Xinyu,
Li Yulin,
Wang Ling,
Huang He,
Li Jing
Publication year - 2016
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12855
Subject(s) - medicine , hazard ratio , hyperuricemia , meta analysis , confidence interval , stroke (engine) , diabetes mellitus , odds ratio , cohort study , medline , uric acid , endocrinology , mechanical engineering , political science , law , engineering
The aim of this study was to assess the prognostic value of hyperuricemia in patients with established hypertension by systematic review and meta‐analysis of cohort studies. MEDLINE , Embase, and the Chinese Biomedical Literature Database were searched through January 2015. Seventeen cohort studies were included and their methodological quality was moderate to high, with Newcastle‐Ottawa Scale scores ranging from 6 to 9. Random‐effects model meta‐analyses showed that in terms of adjusted categorical data, hyperuricemia significantly correlated with cardiovascular diseases in hypertensive patients (hazard ratio [ HR ], 1.51; 95% confidence interval [ CI ], 1.13–2.03), all‐cause mortality ( HR , 1.12; 95% CI , 1.02–1.23), and diabetes ( HR , 1.84; 95% CI , 1.02–3.30) but not with stroke ( HR , 0.85; 95% CI , 0.57–1.27); while, in terms of adjusted continuous data, the corresponding pooled HR s were 1.17 (95% CI , 1.07–1.27), 1.05 (95% CI , 0.98–1.13), 1.28 (95% CI , 1.18–1.38), and 1.06 (95% CI , 0.98–1.16), respectively. The findings of our meta‐analysis suggest that hyperuricemia could slightly increase the risk of cardiovascular diseases and diabetes in patients with hypertension.